Archive for October, 2007

Vernalis Said That The New Diet Drug Similar to Rimonabant Is Promising

Rimonabant news 2007 No Comments »

The UK company, Vernalis, announced on Sept. 13th ,that they are developing a new diet drug that it’s similar to Rimonabant, V24343, and it had produced “outstanding weight loss” in persons in two small phase I at the clinical trials.As an exemple one patient lost 24 pounds in a couple of weeks.

The Vernalis medication, just as Rimonabant, is a CB-1 receptor antagonist which is acting by targeting the CB-1 receptor located in the brain and blocking a person’s desire to eat. Vernalis said that their results on the weight loss produced by the new drugits drug are compareble with results for rimonabant.

Average weight loss after 15 days was 1 pound for the overweight and mildly obese patients given a placebo, 5 pounds for those on a 5 mg dose of V24343 and 10 pounds for those on a 100 mg dose.

But Vernalis,the producer of the new drug ,rival of Rimonabant, said results for V24343 from its early tests showed “a reduced intensity for neurological adverse events” and “a lower rate of appearing of nausea and GI disturbance.”

In this time Rimonabant has been approved and is on sale in contries from Europe, and it will be soon in the United States

Vernalis declared that the worries over “risks off depression and this kind of disease, may be relevant to this sort of drug. Despite that fact, the question as to whether or not other CB-1 antagonists can improve efficacy but with the elimination of major side effects is still open.”

Merck and Pfizer,pharmaceutical giants are a very much ahead of Vernalis,another rival of Rimonabant in investigating this, with medications that target the CB-1 receptor located in the brain already in large phase III trials.

Vernalis CEO Simon Sturge, declared that his company was very happy by these preliminary results which, only if will be confirmed by some longer investigations, will bring significant benefits to overweight and obese persons,just or better than Rimonabant.

Obesity solution

Obesity No Comments »

A closer look on Rimonabant for Obesity solution

At the latest European Society of Cardiology Congress, new reports about how effective rimonabant is in treating obesity. Rimonabant, an investigational drug produced by Sanofi-Aventis, it’s very effective in helping patients to lose weight and quit smoking. The newest trials with this drug are very promising.

In their latest trial, 1507 overweight and obese persons were treated by receiveing either placebo or one of two doses of rimonabant (5 mg or 20 mg per day.). People taking 20 mg rimonabant had loss weigh very much,but in the same time their lipid profiles improved, compared to people who were on placebo. (Those taking 5 mg still loss more weight than placebo patients, but the weight loss wasn’t that big .) Plus all that, waist measurements improved a lot in persons treated with rimonabant.

In those taking the 20 mg dose, almost 42% of patients lost 11% of their baseline body weight, HDL cholesterol (the good cholesterol) increased by 29%, and triglycerides decreased by 11%. More then that, the number of persons with metabolic syndrome was drop at half at persons taking 20 mg rimonabant.

In conclusion investigators said that rimonabant has a direct positive effect on lipid metabolism.

Is rimonabant really that good can we say that its a real obesity solution?

That we are going to see. While all the positive aspects of rimonabant appear more and more every day,there are few possible side effects,but nothing to worry for now.

Despite the fact that the drug it’s allready on the market its long-term effects (both good and bad) will need to be teased out and after that we can say it is a solution for obesity. Some results from a long-term study with rimonabant, is going to be revealed in November, and this is going to be a major step in the problem of the side effects.One thing its sure Rimonabant acomplia really works and comparing to other weight loss drugs it has few side effects.

Answers-Acomplia

Questions and Answers related to Acomplia 40 Comments »

Please if you have any questions about the new weight loss pill Rimonabant Acomplia post them here.

We will be glad to help you find the best solution for obesity .

Best Obesity solution - Rimonabant-acomplia

rimonabant No Comments »

Obesity was a rare occurrence, a few years back. It is no more so. At one time people identified obesity as the cause for some underlying physical disorder or mental disability, so they sought to control excess weigh. But later obesity by and large came to be viewed and specified as being the symbol of good health or good personality. Remarks like “how healthy he looks!” “What a personality he has!” are not uncommon. Even in families where no one is obese, we find children who are either obese from childhood or become obese a few years later.
Obesity also affects youngsters who have reached marriageable age. They find difficulty in getting married as most suitors’ dislike to get saddled with an obese partner especially girls. An overweight male is viewed to be a majestic personality who commands respect and even fear in some cases. However in case of females they are ridiculed, rejected in marriage alliances and even despised in some cases. This is one of the many reasons why women are more figures conscious than men, always seeking various devices than men, always seeking various devices are and health programs to reduce their weight.
Some still equate obesity with perfect health. If one losses a few pounds of excess weight people lament often about how good his health was some days ago and how weak he looked after losing weight. Nevertheless today many people are well informed through various health column, articles and news items published in periodicals & papers about why obesity is not desirable and why one should control excess weight. People now realise that obesity causes a variety of disorders, some of which could prove life threatening.
Obesity put strain on heart, respiratory and eliminatory system. It also increases the chances of diabetes, hypertension and heart diseases. Generally it is seen that obese people are also lower in vitality.

Obesity occurs in mostly two types of people. In stressful people who eat very fast and in excess and secondly in household person who eat from boredom. As the people put on weight they tend to become less happy because of their appearance and become more frustrated. Some people think by taking insufficient food can help in reducing weight. But when they start dieting, body starts to slow down in order to conserve energy and boost its chances of survival. This is why weight loss tends to slow down as we continue to diet. So in a way dieting is not the good method for reducing weight.

The most common cause of obesity is overeating and less physical movement. Overeating problem is coupled with poor diet and also wrong timing of eating said Subodh Gupta, Yoga expert from India. In fact to fight growing obesity among children, some of the schools in the UK are planning to introduce yoga for thousands of young students. This is an excellent step in the direction of fighting the obesity problem of UK.

Yoga practice provides an excellent means for maintaining balanced weight and overcoming obesity problem, provided a daily yoga program is followed with regular routine according to Subodh Gupta Yoga expert based in London.
irst of all we need to find out a reason for this growing mountain of fat that is killing us.

We know now that the traditional explanation - that of overeating - is wrong. People eat when they’re hungry, and they stop when they’re full. The problem lies in hormonal imbalance inside our bodies, an imbalance that deprives us of the energy to live life to the full, and instead stores the energy as fat.

What influences human hormonal balance? The three biggest factors are: genetics, diet, and stress.

There are no prizes for guessing which one of those three is the easiest to control.

The number one nutrient that negatively affects human hormonal balance is well known - it’s sugar. The health and beauty of nations is directly related to its consumption. The per capita consumption of sugar has increased fifteenfold over the last 100 years.

Ever wondered why the French remain slim despite eating far more calories than we do, with their rich, fatty cuisine? That’s right, it’s because they drink wine instead of soft drinks!
The best obesity solution that I can think of is Diet weight control isn’t as easy as it sounds. People often assume that when they reach their target weight that they can stop their diet and they will remain slim and healthy but obviously that is not the case. To continue being slim and healthy you must keep the weight of one preferred method is through diet weight control.

There are a few solutions to obesity available but surgery is maybe the most severe. If you plan on loosing weight try it the healthy safe way many websites and slimming clubs offer up diet plans as a way of getting you to stick to your targets and goals
Therefore achieving desired weight loss. When asked what is a perfect weight people say many different things. Some people think a size 12 is a perfect weight while others think being happy in yourself at your weight is perfect. Health officials have decided the perfect weight is to measure your BMI which is your size to weight ratio.
If you are obese then you need to do something about it as being obese contributes to health problems later on in life such as diabetes and coronary heart disease (CHD).

Obesity solutions do not come in the form of quick weight loss diets and these type of diets should be avoided. Quick fix diets such as the Atkins diet which consists of no carbohydrates and high protein foods is extremely dangerous. These types of weight loss diets are terrible for the body, not only that once the weight is of it is very hard to keep off. Although these diets are recommended by stars such as models and singers it is not safe to use them.
Also the best obesity solution i think its the new drug luched by sanofi aventis(Rimnabant-acomplia).
Acomplia Rimonabant , discovered and developed by French pharmaceutical company Sanofi-Synthelabo, is a new drug thas has shown great promise in trials for the treatment of obesity and related metabolic risk factors.

How does Acomplia work?

Acomplia works on the so called endocannabinoid system, which is a system in the brain that affects energy balance, glucose and lipid metabolism and body weight. The result is that patients will experience the feeling of being full easier thus wanting to eat less than normally. This has been proven to significantly help obese patients achieve a weight loss if used in conjunction with a calorie reduced diet and exercise.

Diet Drug Acomplia Reduces Fats very much

Acomplia news 2007 No Comments »

A Study found that Diet Drug Acomplia Reduces Fats very much

In a multi-center study in Japan Diet drug Acomplia (rimonabant, online is the way that you can buy it) was found to reduce very much human visceral fat — the dangerous abdominal fat –,that was announced of Sanofi-Aventis on Sept. 18th.A report on the study was presented at
this year meeting of the European Association for the Study of Diabetes and it talks about the first direct evidence of the way that rimonabant (Acomplia / Zimulti which can be found online) is decreasing the metabolically active fat.That refeares to the fat which surrounds some vital organ as the pancreas and liver.

Researchers reported that the visceral fat area was more  reduced in the study, in 526 obese Japanese participants that were taking the customary 20 mg rimonabant dosage (-40.6cm2) than for those taking a placebo (-20.3cm2).

In the human body exist a couple of adipose tissue, which are characterised by differences:anatomical and metabolic.

The subcutaneous fat is located directly under the skin and contains insulin-sensitive adipocytes (fat cells)very small , while the visceral fat (inter-abdominal adipose tissue),that surrounds the abdominal organs , contains large adipocytes that are insulin-resistant.

Visceral fat in excess, present in patients with abdominal obesity, goes to metabolic imbalance, such as lipid disorders, resistance to insulin and type 2 diabetes, which eventually will lead to cardio-metabolic disease.

So the study shows that Acomplia(rimonamant can be bought online) is very good for the human body.