Acomplia produced disappointing results in slowing progression of coronary artery disease in patients and it significantly raised the risk of anxiety and depression, according to a report in the April 2 issue of the Journal of the American Medical Association.
More than 20 percent of patients who took rimonabant in the STRADIVARIUS trial developed psychiatric problems, the researchers reported.
While Acomplia is sold in European Union countries and some other nations, Sanofi Aventis pulled back its U.S. application last year after an FDA advisory panel recommended against approval of rimonabant because of concerns over psychiatric risks.
The researchers reported that the study failed to meet its main goal of reducing the Percent Atheroma Volume (PAV), a measure of plaque in a cross-section of the arteries, although it did reduce the Total Atheroma Volume (TAV), a measurement of total plaque in the coronary artery.
But more attention seems certain to be focused on this latest effort to assess the extent to which Acomplia carries with it an increased risk of psychiatric side effects.
The researchers in the STRADIVARIUS study included patients with a history of such problems, and reported that 23.4 percent of patients who got Acomplia suffered psychiatric side effects such as depression and anxiety compared to 18.4 percent of patients who were in the control group.
But despite that ,reserchers have also goosd news about Acomplia.They descovered why this amaizing diet pill has some side effects.
Acomplia, in addition to promoting weight loss by blocking the body’s CB-1 receptors, may also block a receptor in the brain called TRPV1, possibly explaining why the diet pill produces depression, anxiety and suicidal thoughts in some patients, according to researchers.
“It’s possible that when people are taking the drug rimonabant, and the dose range is correct, it may not affect TRPV1 at all,” A specialist said. “However, in some people, Acomplia could be hitting TRPV1 and may well have an effect on activating this receptor,so the solution could be here”
So with the right dosage Acomplia may not affect people at all,but now this great discovery people could use a higher dosage without any side effect.
This is a great news for all over weight people ,that need help to change their lifes,so all we can hope now is that reserchers use properlly this discovery and the FDA finally to aprove this amaizing pill,Acomplia .
Archive for the 'acomplia' Category
The European Commission has decided to let Sanofi-Aventis inform patients taking diet drug Acomplia (rimonabant) that the pill may also help in diabetic blood sugar control, but that does not mean it is approved to be prescribed as a diabetes drug for now.Further investigation are necessary to decide if acomplia can pe prescribed as blood sugar contol medicine.
The actual information , approved by the European Commission in the summer of 2006, authorize use of Acomplia in Europe as an adjunct to diet and exercise for treatment of obese patients or overweight patients with the risk factors such as type 2 diabetes or dyslipidaemia.
Rimonabant,an experimental wonder drug helps you lose weight, quit smoking and it also helps protect your heart. Trials have shown that 33% of people on Rimonabant lost 10% of body weight and kept their weight down for two years - this is a record, no other diet drug has managed to keep a person’s weight down for so long.
The second 33% lost 5% of body weight and kept it down.
It works by blocking endogenous cannabinoid binding to neuronal CB1 receptors. Activation of these receptors by endoegenous cannabinoids, such as anadamide, increases appetite. It is the most advanced endocannabinoid receptor antagonist in clinical development and offers a novel therapeutic approach to appetite control and weight reduction.
Rimonabant may also be found to be effective in assisting some smokers to quit smoking. Sanofi-Aventis is currently conducting studies to determine the possible value of rimonabant in smoking-cessation therapy. The Studies with Rimonabant and Tobacco Use (STRATUS) Program involves more than 6,000 subjects. STRATUS is designed to explore two smoking-related therapies: first, to use rimonabant directly to aid in smoking cessation; second, to help prevent weight gain in former smokers. Initial results apparently suggest that rimonabant is effective for both uses.
Tetrahydrocannabinol is known to impair short-term memory.
It was therefore hypothesised that Rimonabant may improve short-term memory. Indeed in animal studies it significantly improved the performance of rats to encode information in the short-term memory.
Acomplia (rimonabant) is also usefull in diabetic blood sugar control.
Based on eight trials now underway, Sanofi Avensis want to submit diet drug Rimonabant Acomplia for worldwide approval as a treatment for type 2 diabetes in 2009, and the European decision to allow inclusion of results from a diabetes studies on the insert suggests more off-label use of the medication for treating diabetes may occur any time soon.
The results come from the so-called SERENADE trial, which compared use of Acomplia to improve blood sugar control (as indicated by the patient’s HbA1c level, a measure of glucose control) in 276 newly diagnosed type 2 diabetic patients who had not yet been treated with any diabetes drug.
In the trial, scientist declared that those on rimonabant treatment saw an average decrease in their HbA1c level of 0.8 compared to 0.3 for those on a placebo, with 51 percent of those on diet drug acomplia rimonabant achieving the treatment target level recommended by the American Diabetes Association.
So based on the facts and the studies we sincearlly recommend the use of Rimonabant,a drug that can help you in so many ways and that can improve the quallity of your life.
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You can find here all the news related to the new weight loss pill and information on where you can order Acomplia (Rimonabant/Zimulti) online for weight loss. Acomplia Rimonabant is a new weight loss drug by Sanofi aventis to fight against obesity. Acomplia Rimonabant (Zimulti) also helps at some extent to quit smoking and for diabetes treament. You can Buy Acomplia Rimonabant from our website for obesity/weight loss treatment.
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What Is Rimonabant?
A single pill Rimonabant has been found to stop food craving enough to help people lose weight, and could also help curb other unhealthy urges. Named Rimonabant Acomplia the drug in one study helped people who were overweight drop an average of 20 pounds and very useful for the patients who suffer from obesity. Rimonabant Acomplia is made by French firm Sanofi-Synthelabo and the company says it is available now in
Clinical data on Acomplia has shown that nearly of the one third of patients treated with 20 milligrams of Acomplia over the full two years lost an excess of 10 per cent of their initial body weight. More than 62 per cent of 20 mg Acomplia patients shed at least 5 per cent of body weight. Waist circumference at two years was reduced by 3.1 inches (8 cm) in the 20 mg Acomplia group, by 1.9 inches (4.9 cm) in a 5 mg Acomplia group, and by just 1.5 inches (3.8 cm) in the placebo group. Across all measures, Acomplia 20mg was more effective than the lower dose and significantly better than placebo.
Overall benefits of Acomplia Rimonabant included an increase in HDL levels by 24.5 per cent and triglyceride reduction by 10 per cent � twice what would be expected from the degree of weight loss as per the research conducted. A single pill Rimonabant has been found to stop food craving enough to help people lose weight, and could also help curb other unhealthy urges. Named Rimonabant Acomplia the drug in one study helped people who were overweight drop an average of 20 pounds and very useful for the patients who suffer from obesity. Rimonabant Acomplia is made by French firm Sanofi-Synthelabo and the company says it is available now in
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Clinical trials with a new anti-obesity drug Rimonabant (acomplia) look promising for the weight loss. The drug rimonabant was developed after scientists noticed that cannabis smokers often had increased appetites and frequently experienced the‘munchies’. Rimonabant (acomplia) is the most trust full pill for obesity. And Rimonabant side effects are very mild so we can use Rimonabant without any fear.
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Rimonabant acomplia block the cannabinoid receptors in the brain that reduce appetite. Blocking these receptors by rimonabant, might also help people to controlling food intake and you will start losing your weight by rimonabant. New study published in medical journal The Lancet, confirms the rimonabant acomplia can help in weight loss and reduce the risk factors associated with heart disease.So buy Rimonabant (Acomplia) for effective weight management.
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NEW YORK: Do fat pills work? Are they safe?
Dr. CELESTE ROBB-NICHOLSON : Scientists are studying factors that influence how full we feel and how fast we burn calories. Prescription weight-loss drugs–which include phentermine (sold as Adipex-P and other brand names), sibutramine (Meridia) and orlistat (Xenical)–can temporarily manipulate some of these factors. Another new drug, acomplia without prescription, which blocks an appetite receptor in the brain, is awaiting approval from the Food and Drug Administration. (And Xenical may be available over the counter later this year.) The National Institutes of Health recommends that weight-loss drugs be given only to people with a body-mass index (BMI) over 29–or 27, if the patient has weight-related problems like type 2 diabetes, high blood pressure or arthritis. They should be taken in conjunction with lifestyle changes and they do have side effects, so check with your doctor. Those who lose weight and keep it off generally …
As the number of overweight Americans grows, so does the number of frustrated dieters. For some, turning to drugs or surgery might actually be a better answer than calorie counting and yo-yoing up and down on the scales.Nearly one in three Americans fits the definition of obesity–a body mass index (BMI) of 30 or higher (see page 6 to calculate). About 5% of Americans are “morbidly obese,” with a BMI of 40 or higher, or about 100 pounds overweight.
Even if you’re lucky enough not to fall into either category, it’s likely you know someone who does. And although controversy abounds about the health implications for people who are slightly overweight (see EN, June 2005), there is no equivocation about people who are severely overweight. Obesity clearly increases your risk of health problems, especially high blood pressure, diabetes, heart attack and stroke, and increases the risk of death. acomplia without prescriptionFor people who have struggled to lose weight with diet and exercise, prescription medications are one choice. But for those who are severely overweight and suffering from medical conditions exacerbated by extra pounds, surgery may be an even better option. Note: It’s important to understand that drugs and surgery do not take the place of diet and exercise, which are still essential.acomplia without prescription
How to know who might benefit the most from either option? EN reviews the latest drugs for weight loss, as well as the criteria for weight-loss surgery.
Rx Choices. As a rule, prescription weight-loss medications are for people with a BMI of at least 30, or a BMI of 27 if they also suffer weight-related health conditions, such as high blood pressure, high blood cholesterol or type 2 diabetes.With diet drugs, most weight loss occurs within six months of starting treatment, after which body weight tends to level off or even increase. And as with all medications, weight-loss drugs can have side effects that may ultimately determine which drug is right for you. We’ve categorized them into three groups.
Acomplia Rimonabant Now Available For Purchase
If you have even a passing interest in the topic of rimonabant, then you should take a look at the following information. This enlightening article presents some of the latest news on the subject of rimonabant.
It seems like new information is discovered about something every day. And the topic of rimonabant is no exception. Keep reading to get more fresh news about rimonabant.
Acomplia (rimonabant) has been licensed in the UK only for obesity treatment and not for smoking cessation. Although during clinical studies the drug clearly demonstrated a reduced craving for nicotine in patients the drug has only at the moment been approved treatment of obesity. As this is a prescription medication we strongly advise consulting your doctor or a certified physician. Our service is not/should not be considered as an alternative to the treatment advice your doctor can provide.
Acomplia purchase, the obesity panacea pill for weight control has been released for sale on prescription in the UK on 21st June 2006. Available in 20mg tablets, it has to be taken daily on prescription of a certified doctor from 121doc.com.
How does Acomplia work
Acomplia works directly on the urge or craving to eat more. This is accomplished by working on the endocannabinoid system, a system affecting energy balance, glucose and lipid metabolism and body weight. Blocking certain receptors in the brain will result in the patient experiencing the feeling of being full thus wanting to eat less than normal. Along with using in conjunction with a calorie reduced diet and exercise it significantly helps obese patients achieve a weight loss.
How much weight can be lost on Acomplia
More than 6800 patients have undergone placebo-controlled studies using Acomplia with substantial results. In the subsequent phase 3 trials a dietician prescribed a diet for patients and they were asked to increase physical activity/exercise.
On the completion of a year and taking an Acomplia 20mg pill daily a mean weight loss of 6.5 kg was observed as compared as 1.6kg with a placebo. The first 9 months were the most crucial in which significant weight loss was achieved.
It was also observed that the risk of regaining weight was quite lower using Acomplia.
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A new animal study on rimonabant (Acomplia / Zimulti) has identified yet one more possible health benefit for this controversial diet drug: it appears to reduce obesity-related liver damage that can lead to cirhossis of the liver. A team of researchers led by Mohammed Bensaid of Sanofi-Aventis, the company that has developed rimonabant, reported on these latest developments in the July 2007 issue of Hepatology, the official journal of the American Association for the Study of Liver Diseases. In their study involving liver function in obese rats, the researchers said they found that rimonabant reduced markers of liver damage, decreased levels of pro-inflammatory proteins, and improved lipid profiles. Male obese rats were given rimonabant orally daily for 8 weeks and had their food intake monitored; control animals received the same amount of food as those receiving rimonabant. The researchers reported the results showed treatment with rimonabant reduced liver enlargement, completely abolished hepatic steatosis, and decreased blood levels of enzyme markers that indicate liver damage. It also strongly reduced levels of hepatic TNFa, a pro-inflammatory protein thought to induce insulin resistance in the liver and be involved in the progression of steatosis to hepatic fibrosis and cirrhosis. “Our hypothesis is that the multi-protective effects of rimonabant may be mediated for a large part by both the reduction in pro-inflammatory cytokines such as TNFa and the increase in anti-inflammatory and protective cytokines or hormones such as adiponectin,” the researchers said. “This suggests a potential clinical application for this CB1 receptor antagonist in the treatment of liver diseases associated with obesity and the metabolic syndrome,” they added. The researchers also emphasized that these results on Acomplia diet drug were not (or were only slightly observed) in the control animals eating the same diet but not given rimonabant, demonstrating the beneficial effects of the drug compared to diet alone. |
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Buy Acomplia Rimonabant, a new class weight loss pill manufactured by French pharmaceutical Sanofi-Aventis. Rimonabant Acomplia works in a very unique way from other weight loss drugs like Xenical, hoodia or Reductil/Meridia and thus Acomplia Rimonabant (Zimulti) is most popular amongst all obese people.
Acomplia Rimonabant (Zimulti) Ingredients
In Acomplia drug, Rimonabant is the active ingredient which works on the principle of an appetite suppressant. The CB-receptors in the body are responsible for regulating food intake of the body. Usage of Acomplia (Rimonabant) basically obstructs the functioning of these CB-1 receptors, thereby decreasing your appetite. This activity in turn leads to weight loss. A combination of proper diet and regular workout regime along with Acomplia drug (Rimonabant) can pave path for an effectual weight loss.
Acomplia Rimonabant (Zimulti) Approval in Europe UK and USA by FDA and EU Union
Acomplia drug (Rimonabant) has been approved in the UK, Germany, Sweden, and Finland and USA as well by brand name Zimulti amid other countries with prescription. The benefits of Acomplia drug (Rimonabant) apart from weight loss can be accounted as improvements in the cardio metabolic risk factors, smoking cessation, minimization of chances of weight regain are to mention a few.
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Could Have Impact on Treatment of Addiction
A new anti-obesity pill that has been shown to not only help lose weight and quit smoking could also be effective in helping people stop drug and alcohol addiction, scientists claim. Acomplia, or rimonabant, is an experimental drug developed by the French pharmaceutical firm Sanofi-Aventis primarily as a diet pill, but the drug works differently that most diet pills in that it blocks the brain’s reward system.
It works by blocking the connection between a pleasure-seeking activity, like smoking or overeating, and the reward “feeling” it causes in the brain. The human body contains endocannabinoids, marijuana-like substances that can stimulate the brain’s reward system.
Acomplia blocks the effect of the natural endocannabinoids by keeping them from attaching to the brain cells they usually stimulate, scientists say.
In March of this year, Acomplia gained a great deal of attention when two research studies demonstrated that it could not only help people lose weight, but quit smoking also. Last week, researchers reported rimonabant helped keep weight off for two years, lower bad cholesterol, increase good cholesterol, and it could possibly be used to fight drug and alcohol abuse.
Acomplia Side Effects
Sanofi-Aventis will begin the process of seeking Food and Drug Administration approval for use of Acomplia in the United States. That process could begin as early as next year. Once the drug is approved for use as a diet pill in the U.S., it can then be studied for its effect on addicts and alcoholics, researchers say. However, the two-year study of Acomplia showed some side effects including depression, anxiety, and irritability. Researchers reported that those side effects were mostly minor and short-lived. But 13 percent of those in the trial who took the most effective dose of the drug, stopped taking it and dropped out of the study due to those side effects.
Some scientist have expressed concern about the mental side effects of the drug and some believe that the FDA will want to carefully study the long-rage use of the drug for possible risk factors before giving its approval, which could take years.
