Rimonabant - Acomplia online

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admin — Mon, 19 May 2008 12:50:51 +0000

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New facts for Acomplia side effects

admin — Thu, 24 Apr 2008 00:17:52 +0000

Acomplia produced disappointing results in slowing progression of coronary artery disease in patients and it significantly raised the risk of anxiety and depression, according to a report in the April 2 issue of the Journal of the American Medical Association.
More than 20 percent of patients who took rimonabant in the STRADIVARIUS trial developed psychiatric problems, the researchers reported.
While Acomplia is sold in European Union countries and some other nations, Sanofi Aventis pulled back its U.S. application last year after an FDA advisory panel recommended against approval of rimonabant because of concerns over psychiatric risks.
The researchers reported that the study failed to meet its main goal of reducing the Percent Atheroma Volume (PAV), a measure of plaque in a cross-section of the arteries, although it did reduce the Total Atheroma Volume (TAV), a measurement of total plaque in the coronary artery.
But more attention seems certain to be focused on this latest effort to assess the extent to which Acomplia carries with it an increased risk of psychiatric side effects.
The researchers in the STRADIVARIUS study included patients with a history of such problems, and reported that 23.4 percent of patients who got Acomplia suffered psychiatric side effects such as depression and anxiety compared to 18.4 percent of patients who were in the control group.
But despite that ,reserchers have also goosd news about Acomplia.They descovered why this amaizing diet pill has some side effects.
Acomplia, in addition to promoting weight loss by blocking the body’s CB-1 receptors, may also block a receptor in the brain called TRPV1, possibly explaining why the diet pill produces depression, anxiety and suicidal thoughts in some patients, according to researchers.
“It’s possible that when people are taking the drug rimonabant, and the dose range is correct, it may not affect TRPV1 at all,” A specialist said. “However, in some people, Acomplia could be hitting TRPV1 and may well have an effect on activating this receptor,so the solution could be here”
So with the right dosage Acomplia may not affect people at all,but now this great discovery people could use a higher dosage without any side effect.
This is a great news for all over weight people ,that need help to change their lifes,so all we can hope now is that reserchers use properlly this discovery and the FDA finally to aprove this amaizing pill,Acomplia .

Rimonabant vs Taranabant (results report)

admin — Fri, 11 Apr 2008 23:48:36 +0000

What is??

Rimonabant works by blocking the CB1 receptor, one of two receptors found in a newly described physiological system called the Endocannabinoid System (EC System), believed to play a critical role in the regulation of food intake and energy expenditure and it also helping by normalizing the over-activation of the EC system and making hunger or cigarette pangs more manageable.

Taranabant is a highly selective blocker of the cannabinoid-1 receptor (CB1R), which is believed to be responsible for regulating weight by impacting appetite and food intake, satiation (the feeling of satisfaction or fullness after a meal), energy expenditure and cravings.

Trial results

Phase III multicentre Rimonabant In Obesity (RIO) trials: Sanofi-Aventis SA, the world’s third biggest drug maker, said its experimental anti-craving pill, rimonabant, helped obese patients to lose their weight about 27 pounds and trim 4.5 inches from their waists. Among patients, 44.2% of patients treated with rimonabant 5 mg/day lost more than 7% of their initial body weight, compared to 67.4% of patients in the 20 mg/day group. Where as 5.3% of patients on rimonabant 5 mg/day lost more than 15% of their initial body weight compared to 39% of those on 20 mg/day.The weight that was lost wasn’t gained back for the next 2 years.

Phase III study of Taranabant:In this study, patients taking taranabant 2 mg experienced more than double the amount of weight loss at 52 weeks compared to patients treated with placebo. Patients on taranabant 2 mg demonstrated a mean weight loss reduction from baseline of 4.6 kg (95 percent CI: 6.4 kg to 4.9 kg) compared to 1.8 kg (95 percent CI: 2.3 kg to 1.4 kg) for patients on placebo, which was statistically significant (p<0.001 vs. placebo), at 52 weeks. Maximum weight loss in this study was achieved by week 36 and was maintained throughout the next 16 weeks of the study in patients taking taranabant 2 mg.

Side effect

Rimonabant has some common side effects whitch are known to include:depression, anxiety, insomnia, disorientation, nausea, hallucinations, headache, hypertension, kidney and heart damage, heart attack, palpitations, strokes, and hyperphagia, dizziness and gastrointestinal discomfort.Another side effect of rimonabant are suicidal thoughts,but this appear only in patients that are on antidepressent drug also.

The result of Tarabant are worse than we expected,because by taking tarabant people are not lossing weight ,but they suffer major side effect. Analyst Aileen Salares, in a research report based on an abstract of data from the two-year Phase III trial of taranabant, said the diet pill did not live up to expectations and had worse psychiatric and neurological side effects than anticipated.She added that the safety profile of the 2 milligram dose of the drug was “not nearly as clean as expected” with twice as many participants dropping out of the trial because of psychiatric side effects as patients taking a placebo.

Other benefits

Rimonabant can be used also as a pill for helping people quit smoking. Althought Rimonabant has not officially been approved for use as a smoking cessation aid, its effects on smoking are quite encouraging. Acomplia helps people with other problems and diseases such as diabetics,cardiovascular risks and the newest one is resistens to alcohol fat building effect in the liver. Alcoholic fatty liver is a cause for more serious disease.

Taranabant:The one-year study involved 414 patients randomly assigned to take 2 milligrams of taranabant daily and 417 patients given placebo.Results showed that patients reached their lowest weight about nine months into the study. They were then able to maintain that weight for the rest of the year, Aronne says.Patients taking taranabant also experienced a rise in levels of HDL”good “ cholesterol and a drop in triglyceride levels.

A Few Reason for Rimonabant’s Side Effects Were Recently Discovered

admin — Sun, 23 Mar 2008 19:24:49 +0000

Rimonabant is widely available outside the United States, including in Eurolpe for a log time now, but Sanofi Aventis pulled it back from consideration by the U.S. FDA last summer after an agency advisory panel unanimously expressed concern over the drug’s psychiatric side-effects and they refused to approve it.

The weight-loss drug rimonabant has been associated with troubling psychiatric side effects, and now researchers think they have discovered the reason.

A receptor in the brain called TRPV1, which is central to learning and memory, may be blocked by large doses of rimonabant (Acomplia), resulting in depression, anxiety and suicidal thoughts among some people taking the drug, a new study shows.

“It’s possible that when people are taking the drug rimonabant, and the dose range is correct, it may not affect TRPV1 at all,” . “However, in some people, Acomplia could be hitting TRPV1 and may well have an effect on activating this receptor,so the solution could be here” said lead researcher Julie Kauer, an associate professor of molecular pharmacology, physiology and biotechnology at Brown University in Rhode Island.

In experiments with rat brains, Kauer’s group found that TRPV1 controls a brain mechanism called long-term depression, which is thought to be a key component in memory. The team thinks this discovering may be related to the psychiatric side effects that have been seen with Acomplia.

In addition, the researchers found that a new class of painkillers may interfere with learning and memory, because they also block TRPV1.

A specialist thinks the study may have identified the main reason for mood disorders associated with Acomplia Rimonabant, but it said that the drug’s benefits outweigh the risks.Despite this fact is this discovering will help Sanofi to eliminate the side effect ,so that Acomplia be totally safe.

“This is an interesting study which is important in potential mechanisms that could explain the higher incidence of mood disorders associated with rimonabant use,” said Dr. Raj Padwal, an assistant professor of general internal medicine at the University of Alberta in Canada.

This study is a really good thing in elucidating potential mechanisms but not really helpful in teasing out whether the drug should be approved, Padwal said. “For approval, I’m sure the FDA is looking for post-marketing surveillance data from Europe and other countries of the world in which the drug is being used,because as we allready know FDA asks more than anybody can give when we’re talking about an european product.” he added.

As a conclusion we can only hope that this latest discoverings will make Acomplia even a better pill.Rimonabant has so many benefits and only a few side effect and now if Sanofi will use this study will make from Acomplia the best diet pill in the world for a lot of years from now.

Rimonabant-a simple solution to obesity

admin — Sat, 23 Feb 2008 13:49:53 +0000

Rimonabant-a simple solution
Rimonabant is the diet pill that made a huge impression in the obesity treatments. Rimonabant is the main ingredient of Acomplia,the best diet drug in the world right now. The researchers at Sanofi Aventis one of the most highly recognized pharmaceuticals developers in the world are “responsible” with the apperence of this amaizing drug,that helps people to lose weight and not suffering major side effects.

What you can expect from Rimonabant?
There is a simple answer to this question: WEIGHT LOSS. It’s fast, easy and simple. But do not think you must not put any effort if you have many pounds to take of. You must do exercises and keep some restrictions in what you eat and how you eat,if your target is really high.
Rimonabant is recommended to be used on people who have a BMI over 30 or a BMI over 27 with associated risk factors. You must never take it while on anti-depressive medication. Rimonabant should be cautiously in people with moderate renal impairment, epilepsy, people using potent inhibitors and rare hereditary disorders and galactose intolerance. In addition those over 75 should take care when using the Rimonabant. Those who should not take Rimonabant include those with uncontrolled psychological disorders, a cardiovascular event in the last six months and patients who are breastfeeding or pregnant.

Scientist declared that when you start taking rimonabant you will start feel it’s benefits. Don’t worry about side effects, they are normal and will pass when the body gets used with the changes of your metabolism.
You must consult your doctor or a weight loss specialist before you buy rimonabant in order to see if rimonabant is a proper drug for you and how much you will need to take rimonabant. Also tell your doctor about all the medicines you use, (prescription and nonprescription) especially if you take: high blood pressure medicine, MAO inhibitors (e.g., furazolidone, linezolid, phenelzine, selegiline, tranylcypromine), any other weight loss pills. Do not start or stop any medicine without doctor or pharmacist approval.

Diet Drug Taranabant Could Pass Fda Test This Summer ,despite Sanofi’s Effort To Get Acomplia On The Us Market

admin — Tue, 05 Feb 2008 08:07:26 +0000

FDA approval of diet drug rimonabant (Acomplia ) failed. That did not happen — in fact, rimonabant may never make it to market in the U.S,
and the great diet hope for 2008 is Merck’s diet drug taranabant.

Everybody knows that there is a big rivality between Sanofi and Merk.
Despite all the efforts Sanofi Aventis failed to get Acomplia in the US market.
Specialists reported that Acomplia is to dangerous because of adverse reaction (patients suffered depression) and suicide risk.
Obese Americans eager to hear more about taranabant got a teaser Jan. 10th, but the generally encouraging report in the January issue of the journal Cell Metabolism was again based on results from a phase II trial and not the big phase III trial underway these past two years.
The news, in fact, was very similar to the report on phase II results that Merck presented at the annual scientific meeting of the Obesity Society back on Oct. 24th. In the journal article, researchers said study participants taking varying doses of taranabant lost 8 to 14 pounds over a 12-week period.
Merck researchers said between one-fifth and one-third of patients in the phase II trial of taranabant experienced psychiatric adverse effects, including depressed mood, irritability, anger, mood swings, tearfulness, anxiety, insomnia, and nervousness.
Presumably, there will be more and better information on side-effect issues when Merck reports on results of its phase III taranabant trial later this year. No date has yet been set for the first reports from this trial.
We hope that Taranabant will have better luck and obtain access in US.
Not that We take their side but We have concrete facts to belive that more and more obese people buy Generic form of Acomplia and the results are slower and the side effects of Rimonabant are not well known.

No adverse reaction were reported with people using rimonabant and the benefits are impressive.

British Medical Journal reports that Acomplia helped people loose weight

admin — Sat, 26 Jan 2008 06:36:23 +0000

Everybody is curios about the last year reports for Acomplia benefits!

As the obesity crisis worsens and more pharmaceutical companies are hoping to improve their bottom line by shrinking their customers’ bottoms. After all, we are a short-cut society (who wouldn’t rather pop a pill than engage in the hard work of exercise and calorie restriction?) with a short memory (remember the fen-phen diet-drug combo that led to a gazillion lawsuits?). The good news is that according to a recent report in the British Medical Journal, three relatively new antiobesity drugs helped patients lose a moderate amount of weight while doing such things as lowering cholesterol and reducing the incidence of diabetes. The bad news is that the list of possible side effects doesn’t end there.

The study found that both of the diet pills the U.S. Food and Drug Administration (FDA) has approved for long-term use may lead to a modest weight loss of about 5% to 10% of a person’s total body mass within the course of a year.

Approved by the European Drug Agency in June 2006 and sold under the name Acomplia, rimonabant takes a different weight-loss route than Meridia, which revs up metabolism and creates a feeling of fullness, and Alli, which reduces fat absorption from food. Rimonabant is the first of a new class of drugs designed to keep the user from getting the munchies. That’s right: knowing that marijuana and other forms of cannabis stimulate the appetite, scientists wondered what might happen if they blocked the brain’s cannabinoid receptors.Not only did the desire for food seem to diminish with rimonabant but other cravings, like nicotine, were easier to control.

The FDA panel nixed rimonabant’s application for approval due to concerns that the drug increases the risk of depression.So basically Fda must obtain more information about It right?

No you see its all politics.We all know that side effects are inevitable but I say that Acomplia its the first diet pill for long term usage with minor side effects.Lets think about Xenical or phentermine this 2 pills are crimal and made lot of trouble and still they were approved.

So why is not Acomplia aprroved in the US.Its simple the USA FDA is waiting for Merck option (manufacturer and distributor of pharmaceuticals) they developed a new diet pill called Taranbant.Even if the trial results of Taranabant are not significant it doesn’t matter.Merck is a Us Laboratory ,so why not wait for them instead approving Acomplia developed by Sanofi Aventis - French Laboratory.

Its not fair but we are talking about business and money here!!

Order Rimonabant to Evade the Obesity Burden

admin — Thu, 10 Jan 2008 00:04:51 +0000

Weight loss drugs have become the need of the hour. This situation can be better understood in the scenario of obesity taking form of a world wide phenomenon. Obesity is recognized as a dietary disorder which in itself being a major health concern, tags along many other health hazards too such as high cholesterol, high blood pressure. In the midst of weight loss drugs, Rimonabant diet pills have conquered the trust of obese who are making a desperate effort to shed those extra pounds. Its popularity among obese is primarily due to its affordability and positive weight loss results.

Rimonabant, which is an oral prescription medication, can help you out in an effectual manner when you are stuck in the grip of obesity. It works by affecting certain neuro-transmitters which regulate our appetite. When these neuro-transmitters are inhibited it causes appetite suppression, thereby causing weight loss. It displays optimistic weight reduction when combined with a proper diet and regular fitness regime. Rimonabant is usually recommended for individuals who have a BMI or Body Mass Index 30 or 27 along with obesity related health risks. BMI or Body Mass Index basically denotes the calculated figure of weight in proportion to height. The higher your BMI, the more chances you have to become prone to cardio-metabolic risk factors.

Rimonabant is usually consumed half-an hour before your breakfast with a glassful of water. The dosage varies from individual to individual in accordance to his health status. Rimonabant diet pills should be consumed as per your doctors’ prescription for effective weight loss results. Rimonabant is also marketed under the brand names of Obitone and Slimona.
A few Rimonabant side effects can be enlisted as:

» Dry mouth

» Insomnia

» Vomiting

» Diarrhea

» Headache

» Constipation

These side effects are a mere reflection of bodily changes to Rimonabant medication, and usually evade within a passage of time. Incase, these side effects persist over an extended period of time, seek immediate help from your doctor. Expectant women and breast-feeding mothers should abstain from intake of Rimonabant. Shelve Rimonabant medication away from moisture and heat.

Online pharmacies can enable you to order Rimonabant with convenience. In fact, you can have your order delivered at your doorstep as well. Some of these online pharmacies can facilitate you to get access to online Rimonabant consultation as well as online Rimonabant prescription, which are free-of-charge. These services can make your order of Rimonabant cost effective. Enjoy the precious moments of your life with your new body shape.

Order Rimonabant and make a sound health decision.

Acomplia (rimonabant), diet pill helps in diabetic blood sugar control

admin — Sat, 01 Dec 2007 08:29:01 +0000

The European Commission has decided to let Sanofi-Aventis inform patients taking diet drug Acomplia (rimonabant) that the pill may also help in diabetic blood sugar control, but that does not mean it is approved to be prescribed as a diabetes drug for now.Further investigation are necessary to decide if acomplia can pe prescribed as blood sugar contol medicine.

The actual information , approved by the European Commission in the summer of 2006, authorize use of Acomplia in Europe as an adjunct to diet and exercise for treatment of obese patients or overweight patients with the risk factors such as type 2 diabetes or dyslipidaemia.

How to avoid Acomplia side effects

admin — Tue, 20 Nov 2007 12:01:07 +0000

How many people have been treated with Acomplia?
Acomplia was granted marketing authorisation in the EU in June 2006. Currently, rimonabant has been launched in 19 countries, including 13 European countries. Up to the end of May 2007, it is estimated that about 240,000 patients have been treated with Acomplia worldwide. Approximately 41,000 patients have been treated with Acomplia in the United Kingdom.

The two-year study of Acomplia showed some side effects including depression, anxiety, and irritability. Researchers reported that those side effects were mostly minor and short-lived.

When taking a diet pill the side effects should be our first problem.You find a diet pill and after that you start looking for information reviews and so on.There are many sites ,blogs articles about diet pills but you must always keep in mind that not everything you will find its true.

In the moment Acomplia is the only pill that treats obesity and has no substantial side effects.

Of course Acomplia can interact different with every person.When you take acomplia your body metabolism is changing(You are not feeling hungry at all) so you eat less and this action will bring side effects like Headaches and dizziness.

Now I will tell how to take acomplia and avoid side effects:

take only one 20mg tablet every day
fallow a low calorie diet if possible-Avoid High-Fat Foods
You should take acomplia in the morning if you can and after breakfast .
Its better if you can follow a schedule to take acomplia at same hour every day.
eat fruits
drink 3 glasses of water in a day and
Drink lemon juice or grapefruit
If you have missed a dose, take it as soon as you remember. Incase, its time for next scheduled dose, do not double your dose.
Acomplia at the same time with antidepressants -is Not indicated-and i mean this
If you are less than 18 years of age. There is no information available on the use of Acomplia in people under 18 years of age
If you can don’t work to hard
Do not take this medicine when breast-feeing
Acomplia tablets include lactose. If you are intolerant to some sugars, contact your doctor before taking this medicine.

So basicaly You need to start a reduced calorie diet if you want to obtain best results. Your doctor should recommend the type of diet required, that suits your specific condition and overall health.

Please add your advices here for more accurate information!!!